PE22.28 – Spray, 30mg (300mcg/spray)
Data Sheet
| Application | Antagonist of the TREK-1 receptor |
| CAS | 1270083-24-3 |
| Molar Mass | 773.895 g/mol |
| Chemical Formula | C35H55N11O9 |
| Amino Acid Sequence | GVSWGLR |
| Synonyms | Spadin Analog, PE2228, TREK-1 Antagonist, PE 22 28, Sortilin Derivative, PE 2228 |
| Storage | Store at ≤4°C, tightly sealed, away from heat, light and moisture. |
| Solubility | Soluble in Water |
| Organoleptic Profile | Clear, colorless liquid |
| Physical Form | Liquid, solved in Deionized Water (Type II), contains BKC for stability purposes. |
| Specification | PE22.28 concentration (per vial): PE22.28 30mg (3mg/mL) ±10% BKC concentration (per vial): BKC 1mg (0.1mg/mL) ±10% |
| Terms | This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering. |
Synthetic Neuropeptide Analogue for Cognitive and Neuroregulatory Research
PE22.28 is a research-grade synthetic neuropeptide analogue studied for its potential relevance in neurotrophic signaling, cognitive modulation, stress-response pathways, and peptide-based nootropic research. As a compound of growing interest in advanced neuroscience investigations, PE22.28 has attracted scientific attention in models involving brain-derived neurotrophic factor (BDNF)-associated pathways, neuroplasticity signaling, and adaptive cognitive resilience.
Researchers have investigated PE22.28 in studies involving neuroregulatory mechanisms, mood-associated signaling pathways, synaptic plasticity models, and peptide-mediated cognitive research. Its emerging investigational profile has made it a notable subject in advanced neuropeptide science.
Supplied in spray format for laboratory and analytical research applications.
Common Research Areas
- Cognitive Modulation Research
- Neurotrophic Signaling Studies
- Neuroplasticity Pathway Investigation
- Stress Response and Mood Signaling Models
- Peptide Nootropic Research
How PE22.28 Works
PE22.28 has been studied for its potential interaction with pathways associated with neurotrophic signaling, synaptic plasticity, and adaptive cognitive regulation. Researchers have explored its relevance in models involving BDNF-related mechanisms, neurochemical modulation, and peptide-mediated neuroregulatory processes.
Its investigational peptide profile has made PE22.28 a recurring subject in advanced nootropic research.
Research Overview
PE22.28 has been investigated across a range of research models involving cognition, neuroprotection, and regulatory pathway studies.
Areas of scientific interest include:
- Neurotrophic pathway studies
- Synaptic plasticity investigations
- Cognitive signaling research
- Stress-response modulation models
- Peptide nootropic pathway research
Its emerging research relevance continues to make it a notable compound in neuropeptide science.
PE22.28 vs Related Compounds
PE22.28 vs Semax
PE22.28 is often researched in neurotrophic and mood-associated signaling models, while Semax is commonly investigated in broader cognitive and neuroplasticity pathways.
PE22.28 vs Selank
Selank is frequently studied in stress-response and anxiolytic signaling research, whereas PE22.28 has drawn interest in neurotrophic and cognition-focused models.
Frequently Asked Questions
What is PE22.28 studied for?
It is commonly researched in cognitive modulation, neurotrophic signaling, neuroplasticity, and peptide nootropic models.
What type of compound is PE22.28?
PE22.28 is classified as a synthetic neuropeptide analogue investigated in advanced neuroscience research.
How should PE22.28 be stored?
Peptide spray formulations are generally stored refrigerated according to laboratory handling protocols.






