ISRIB – Powder, 500mg
Data Sheet
| Application | Integrated stress response (ISR) inhibitor, PERK inhibitor |
| CAS | 1597403-47-8 |
| Molar Mass | 451.34 g/mol |
| Chemical Formula | C22H24Cl2N2O4 |
| IUPAC Name | 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide |
| Synonyms | ISRIB, 1597403-47-8, trans-ISRIB, 548470-11-7, 1597403-48-9, N,N’-(cis-Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide), ISRIB (trans-isomer), ISRIB trans-isomer, 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide, N,N’-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide), N,N’-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] Acetamide, N,N’-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-, 2-(4-chlorophenoxy)-N-{4-[2-(4-chlorophenoxy)acetamido]cyclohexyl}acetamide, 2-(4-chlorophenoxy)-N-[(1s,4s)-4-[2-(4-chlorophenoxy)acetamido]cyclohexyl]acetamide, N,N’-(trans-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide), 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, cis-ISRIB, ISRIB(trans-isomer), N,N’-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) |
| Storage | Store at room temperature, tightly sealed, away from heat, light and moisture. |
| Solubility | Soluble in DMSO |
| Organoleptic Profile | White powder |
| Physical Form | Solid |
| Specification | ≥98% |
| Terms | This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering. |
Integrated Stress Response Modulator for Cognitive and Cellular Resilience Research
ISRIB (Integrated Stress Response Inhibitor) is a research-grade small molecule widely studied for its potential relevance in integrated stress response signaling, protein translation regulation, cognitive resilience pathways, and neuroprotective research. As a highly regarded investigational compound in advanced neuroscience and cellular biology, ISRIB has attracted significant scientific interest in models involving memory-associated mechanisms, proteostasis, and neuronal stress adaptation.
Researchers have investigated ISRIB in studies involving eIF2B-associated signaling, translational control pathways, synaptic plasticity research, and cellular resilience mechanisms. Its investigational profile has made it a notable compound in nootropic and longevity science.
Supplied in powder format for laboratory and analytical research applications.
Common Research Areas
- Integrated Stress Response Research
- Cognitive Resilience Studies
- Protein Translation Regulation Investigation
- Cellular and Neuroprotective Models
- Advanced Nootropic and Longevity Research
How ISRIB Works
ISRIB has been studied for its potential interaction with pathways associated with the integrated stress response, translational control, and cellular resilience signaling. Researchers have explored its relevance in models involving eIF2B-associated mechanisms, stress adaptation pathways, and neuroregulatory signaling.
Its pathway-specific profile has made ISRIB a recurring subject in advanced research science.
Research Overview
ISRIB has been investigated across a range of research models involving cognition, proteostasis, and cellular resilience pathways.
Areas of scientific interest include:
- Integrated stress response pathway studies
- Protein translation investigations
- Cognitive signaling research models
- Cellular resilience mechanism studies
- Neuroprotective pathway research
Its broad research relevance continues to make it a notable compound in research science.
ISRIB vs Related Compounds
ISRIB vs J147
ISRIB is often researched in translational control and cellular stress-response models, while J147 is commonly investigated in neuroprotection and longevity-associated pathways.
ISRIB vs Dihexa
Dihexa has drawn interest in synaptogenesis-focused research, whereas ISRIB is more strongly associated with proteostasis and integrated stress response investigations.
Frequently Asked Questions
What is ISRIB studied for?
It is commonly researched in integrated stress response signaling, cognitive resilience, protein translation regulation, and cellular protection models.
What does ISRIB stand for?
ISRIB stands for Integrated Stress Response Inhibitor.
How should ISRIB powder be stored?
Research powders are generally stored in a cool, dry environment protected from heat and moisture.
